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The TCR genes from the TILs found in the patient‘s resectedmelanoma lesions were cloned and retroviral transduced T cells recognized the MART-1peptide. If no other anaestheticor opioid is given, the patient becomes respon-sive in 1 hr or so due to redistribution of thedrug (distribution t? of diazepam is 15 min),but amnesia persists for 2–3 hr and sedation for6 hr or more

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